Obesity is one of the risk factors for insulin resistance and type 2 diabetes (T2D), an emerging metabolic disease in the US population. The proposed research will lead to many discoveries that will significantly improve the health of US citizens and others suffering from obesity caused T2D by revealing new concepts and ideas that can be used to develop therapies for the prevention and treatment of T2D. Thus, the proposed research is relevant to NIH's mission that pertains to developing new approaches and fundamental knowledge that will help to reduce the burdens of human disability.
Cardiovascular disease is one of the risk factors for nonalcoholic fatty liver diseases (NAFLD), an emerging metabolic disease in the US population. The proposed research will lead to many discoveries that will significantly improve the health of US citizens and others suffering from nonalcoholic fatty liver disease by revealing new concepts and ideas that can be used to develop therapies for the prevention and treatment of atherosclerosis. Thus, the proposed research is relevant to NIH's mission that pertains to developing new approaches and fundamental knowledge that will help to reduce the burdens of human disability.
Cerebral cavernous malformation (CCM) is an abnormal cluster of enlarged blood vessels in the brain, which increases the risk of seizures, progressive neurological deficits, and intracranial hemorrhage. The proposed research will lead to new discoveries that will greatly improve the health of US citizens and others suffering from CCM-related stroke risk by revealing new gene regulation mechanisms that can be used to develop therapies for preventing the onset of CCM. Thus, the proposed research is relevant to NIH's mission to develop new treatment approaches and fundamental knowledge that will help to reduce the burden of human disability.
Abnormal accumulation of lipids in hepatocytes causes hepatic steatosis, an emerging liver disease in the US population. The proposed research will lead to new discoveries that will greatly improve the health of US citizens and others suffering from hepatic steatosis by revealing new concepts and ideas that can be used to develop therapies for the treatment of hepatic steatosis. Thus, the proposed research is relevant to NIH's mission that pertains to developing new approaches/fundamental knowledge that will help to reduce the burdens of human disability.